Our early human ancestors were great travelers moving across great distances over many generations and thousands of years. Our more recent human history is dominated by human colonization as new waves of people traversing the globe using technological innovations and paving a path of incomparable destruction and exploitation that continue to overshadow the lives of millions of people and our very planetary health to this day. In early 2020 Elon Musk, CEO of SpaceX released their campaign to “Occupy Mars” by 2050, joining a long linage of human ventures that have considered places and peoples unknown to them up for grabs and consequently, ownership and exploitation. Fantastic research, technology, international cooperation, and human advancements have come out of space research. However, the idea that life and resources outside our planet or beyond our galaxy is tenacious and remains an influential factor. In this course, we will explore our human future beyond Earth through the lens of our past asking the question is colonization inevitable? Is it possible as described in Star Trek to “explore strange new worlds, to seek out new life and new civilizations, to boldly go where no [hu]man has gone before?” without contaminating, dominating, and destroying that which exists out there? Can we as a species learn from our human past and avoid colonial mistakes? Can we handle discovering new resources without depleting them? How might discoveries made beyond Earth influence the meaning, use, and ideas about our resources here at home? Applying an anthropological lens to understand the human experience of curiosity, travel, expansion, and colonization, this class, dares to dream big and ask hard questions. This discussion-based seminar will read research and popular publications of nonfiction and fiction including a SciFi novel and ethnographic book, view films and documentaries, and look for signs of space in everyday life on Earth. Through assessment activities such as “Taking up Space” students will learn to critically break down and research the role of cultural ideas and how they influence scientific research and discovery.