We are living in times of a genetic revolution. We have sequenced the human genome and are in a position to transform medical treatment in the world. In spite of the advances in DNA sequencing, there remain mysteries in terms of how the cell accesses genetic information and how our genomes are transmitted to progeny cells with such high fidelity. The principles governing chromosome organization have been discovered through advances in biology, physics, statistics and computational sciences. This class will explore advances from the diverse disciplines and discuss the successes and limitations of the different approaches.